--- a/res/res_rtp_asterisk.c
+++ b/res/res_rtp_asterisk.c
@@ -2272,6 +2272,10 @@
 
 		f = ast_frisolate(&srcupdate);
 		AST_LIST_INSERT_TAIL(&frames, f, frame_list);
+
+                ast_debug(1, "Resetting last_seqno and last_end_timestamp to 0 due to SSRC change\n");
+                rtp->last_seqno = 0;
+                rtp->last_end_timestamp = 0;
 	}
 
 	rtp->rxssrc = ssrc;